CLINICAL TRIALS AND OBSERVATIONS Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study
نویسندگان
چکیده
*Raouf Ben Abdelali,1 *Vahid Asnafi,1 Thibaut Leguay,2 Nicolas Boissel,3 Agnès Buzyn,4 Patrice Chevallier,5 Xavier Thomas,6 Stephane Lepretre,7 Françoise Huguet,8 Norbert Vey,9 Martine Escoffre-Barbe,10 Emmanuelle Tavernier,11 Oumedaly Reman,12 Nathalie Fegueux,13 Pascal Turlure,14 Philippe Rousselot,15 Jean-Yves Cahn,16 Veronique Lheritier,6 Yves Chalandon,17 Marie-Christine Béné,18 Elizabeth Macintyre,1 Hervé Dombret,3 and Norbert Ifrah,19 for the Group for Research on Adult Acute Lymphoblastic Leukemia
منابع مشابه
Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.
PURPOSE The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 (N/F) mutations compared with unmutated T-ALL. Despite this, one third of patients with N/F-mutated T-ALL experienced relapse. PATIENTS AND METHODS In a series of 212 adult T-ALLs included in...
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تاریخ انتشار 2011